Hollow fiber liquid-supported membrane technology for enantioseparation of racemic salbutamol by combinatorial chiral selectors

来源期刊：中南大学学报(英文版)2006年第1期

论文作者：焦飞鹏 黄可龙 彭霞辉 赵学辉 于金刚

文章页码：39 - 43

Key words：enantioseparation; liquid-supported membrane; hollow fiber; combinatorial chiral selector; racemicsalbutamol

Abstract: Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2∶1∶1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and theR-enantiomer flux is more thanS-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.0 7.2.

基金信息：the National Natural Science Foundation of China