Recent progress report on DNA B-Z transition modulated by rare earth-amino acid complex and Alzheimer’s disease amyloid beta
来源期刊：JOURNAL OF RARE EARTHS2010年第6期
论文作者：耿杰 曲晓刚
文章页码：820 - 823
摘 要：Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer （LRET） for bioassays, as well as reagents for diagnosis in magnetic resonance imaging （MRI）. In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer’s disease （AD）.
耿杰1,2，曲晓刚1
1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry2. Graduate School of the Chinese Academy of Sciences
摘 要：Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer （LRET） for bioassays, as well as reagents for diagnosis in magnetic resonance imaging （MRI）. In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer’s disease （AD）.
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