Preparation and bioactivity of sol-gel macroporous bioactive glass

Zhihua Zhou~(1,2)) Jianming Ruan~(1)) Jianpeng Zou~(1)) Zhongcheng Zhou~(1)) 1)State Key Laboratory for Powder Metallurgy,Central South University,Changsha 410083,China 2)College of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,China

摘 要：<正>Bioactive glass is well known for its ability of bone regeneration,and sol-gel hioactive glass has many advantages com- pared with melt-derived bioactive glass.3-D scaffold prepared by the sol-gel method is a promising substrate material for bone tissue engineering and large-scale bone repair.Porous sol-gel glass in the CaO-SiO₂-P₂O₅ system with macropores larger than 100μm was prepared by the addition of stearic acid as a pore former.The diameter of the pore created by the pore former varied from 100 to 300μm.The formation of a hydroxyapatite layer on the glass was analyzed by studying the surface of the porous glass by scanning elec- tron microscopy,energy dispersive spectroscopy,X-ray diffraction,and Raman spectra after they had been immersed in simulated body fluid（SBF）for some time,and the porous glass shows good bioactivity.

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