磁性壳聚糖纳米粒子的制备及表征

来源期刊：中南大学学报(自然科学版)2004年第2期

论文作者：李和平 阮建明 黄伯云 王亚东

文章页码：175 - 179

关键词：磁性壳聚糖;纳米粒子;药物载体;制备;性能

Key words：magnetic chitosan; nanoparticles; drug carrier; preparation; properties

摘    要：以市售Fe₃O₄粉末为原料,经化学处理制得纳米Fe₃O₄糊状物;向Fe₃O₄糊状物中加入壳聚糖,制得磁性壳聚糖纳米粒子。用透射电子显微镜观察到Fe₃O₄粒子呈较规则的球形,粒径为8 ~12 nm,分布均匀;包覆壳聚糖以后,粒子粒径增大到10 ~ 15 nm。经红外光谱检测,壳聚糖已包覆Fe₃O₄粒子。用紫外-可见光谱仪检测溶液吸光度的变化来研究包覆粒子的磁响应性,研究结果表明:当无外加磁场时,粒子的沉降速率很慢;当施以磁感应强度为8 mT的磁场时,粒子沉降速率快速增大;磁性壳聚糖纳米粒子具有磁性稳定和靶向性强的优点。

Abstract: Magnetites (Fe₃O₄) powderwas treated by chemical method totransform into nanometersize aqueous slurry. Chitosan and Fe₃O₄ aqueous slurry were mixed by appropriate proportion, and the magnetic chitosan nanoparticles were produced. The morphology and size of the Fe₃O₄ and magnetic chitosan nanoparticles were measured by TEM. The results show that Fe₃O₄ particles and magnetic chitosan nanoparticles are regular sphere with a size rangof 8 ~ 12 nmand 10 ~ 15 nm, respectively. IR results indicate thatthe Fe₃O₄ parti-cles was coated completely by the chitosan. The absorbance was observed byUV-Vis spectroscope to study the magnetic response properties. In the presence of 8 mTmagnetic field, the speed of subsidence was faster than thatof the absence of magnetic field. It indicates that magnetic chitosan nanoparticles have good magnetic properties and target effect.