Syntheses, Characterization and Antitumour Activities of Rare Earth Metal Complexes with 2-(((4,6-dimethyl)-2-Pyrimidinyl)thio)-Acetic Acid
来源期刊：JOURNAL OF RARE EARTHS2006年第1期
论文作者：Song Yumin Wang Liufang Liu Yingqi Qu Jianqiang Jia Xiaofei Wang Yinyue
Key words：2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; complexes; anti-tumour activities; rare earths;
Abstract: Eight rare earth metal (Ⅲ) complexes with 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid, LnL3*nH2O [HL=2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; Ln=La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n=4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and 1H-NMR. The results reveal that carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods. The results show that the suppression ratios of some complexes against the tested tumour cells (HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines) are superior to HL.
Song Yumin1，Wang Liufang2，Liu Yingqi2，Qu Jianqiang2，Jia Xiaofei3，Wang Yinyue2
(1.College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China;
2.State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;
3.Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China)
Abstract:Eight rare earth metal (Ⅲ) complexes with 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid, LnL3*nH2O [HL=2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; Ln=La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n=4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and 1H-NMR. The results reveal that carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods. The results show that the suppression ratios of some complexes against the tested tumour cells (HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines) are superior to HL.
Key words:2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; complexes; anti-tumour activities; rare earths;
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