Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2018年第10期
论文作者：Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan
文章页码：1944 - 1952
摘 要：Magnesium（Mg） alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu（x = 0, 0.2, 0.4, 0.6 and 0.8 wt%） alloys were prepared by selective laser melting（SLM） with alloying copper（Cu） to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid（DNA） replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications.
Cijun Shuai1,2,3，Long Liu1，Mingchun Zhao4，Pei Feng1，Youwen Yang1，Wang Guo1，Chengde Gao1，Fulai Yuan5
1. State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University2. Jiangxi University of Science and Technology3. Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province4. School of Material Science and Engineering, Central South University5. Health Management Center, Xiangya Hospital, Central South University
摘 要：Magnesium（Mg） alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu（x = 0, 0.2, 0.4, 0.6 and 0.8 wt%） alloys were prepared by selective laser melting（SLM） with alloying copper（Cu） to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid（DNA） replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications.
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