Comparison of modified injection molding and conventional machining in biodegradable behavior of perforated cannulated magnesium hip stents
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2021年第4期
论文作者：Haiyue Zu Temitope Olumide Olugbade Lulu Pan Chris Halling Dreyer Dick Ho-Kiu Chow Le Huang Lizhen Zheng Wenxue Tong Xu Li Ziyi Chen Xuan He Ri Zhang Jie Mi Ye Li Bingyang Dai Jiali Wang Jiankun Xu Jian Lu Ling Qin
摘 要：In this study, perforated cannulated magnesium（Mg） hip stents were fabricated via modified Mg injection molding and conventional machining, respectively. Additionally, the stent canal was filled with paraffin to simulate injection of biomaterials. The microstructure, mechanical performance, corrosion behavior,and biocompatibility were comparably studied. Scanning electron microscopy（SEM） and energy dispersive spectroscopy（EDS） showed higher affinity of interstitial element such as oxygen and carbon as consequences of routine molding process. After immersion in SBF, machining stents showed reduced degradation rate and increased deposition of calcium phosphate compared to molding stents. Corrosion resistance was improved via paraffin-filling. Consistently, the hemolysis and in vitro osteoblast cell culture models showed favourable biocompatibility in machining stents compared to molding ones, which was improved by paraffin-filling treatment as well. These results implied that the feasibility of the prepared machining stents as the potential in vivo orthopaedic application where slower degradation is required, which could be enhanced by designing canal-filling injection of biomaterials as well.
Haiyue Zu1，Temitope Olumide Olugbade3，Lulu Pan3，Chris Halling Dreyer1,4，Dick Ho-Kiu Chow1，Le Huang1，Lizhen Zheng1，Wenxue Tong1，Xu Li1，Ziyi Chen1，Xuan He1，Ri Zhang1，Jie Mi1，Ye Li1，Bingyang Dai1，Jiali Wang1，Jiankun Xu1，Jian Lu3，Ling Qin1,5
1. Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong3. Department of Mechanical and Biomedical Engineering, City University of Hong Kong4. Orthopaedic Research Laboratory, Department of Orthopaedics & Traumatology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark5. Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
摘 要：In this study, perforated cannulated magnesium（Mg） hip stents were fabricated via modified Mg injection molding and conventional machining, respectively. Additionally, the stent canal was filled with paraffin to simulate injection of biomaterials. The microstructure, mechanical performance, corrosion behavior,and biocompatibility were comparably studied. Scanning electron microscopy（SEM） and energy dispersive spectroscopy（EDS） showed higher affinity of interstitial element such as oxygen and carbon as consequences of routine molding process. After immersion in SBF, machining stents showed reduced degradation rate and increased deposition of calcium phosphate compared to molding stents. Corrosion resistance was improved via paraffin-filling. Consistently, the hemolysis and in vitro osteoblast cell culture models showed favourable biocompatibility in machining stents compared to molding ones, which was improved by paraffin-filling treatment as well. These results implied that the feasibility of the prepared machining stents as the potential in vivo orthopaedic application where slower degradation is required, which could be enhanced by designing canal-filling injection of biomaterials as well.
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