Preparation and in vitro Release Properties of Mercaptopurine Drug-loaded Magnetic Microspheres
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2013年第6期
论文作者：XU Haixing ZHANG Yu NIU Xiaoqian WANG Ling CHEN Hui ZHANG Xi TANG Qiuhan HUANG Zhijun LIU Hui XU Peihu
文章页码：1231 - 1235
摘 要：Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation method and the mercaptopurine（MER） drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content（DLC）, encapsulation efficiency（EE） and delivery properties in vitro, determined by high performance liquid chromatograph（HPLC）. The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution（PBS） simulated body fluid, at 37 ℃ with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy.
XU Haixing1,2，ZHANG Yu1，NIU Xiaoqian1，WANG Ling1，CHEN Hui1，ZHANG Xi1，TANG Qiuhan1，HUANG Zhijun1,2，LIU Hui1，XU Peihu1,2
1. Department of Pharmaceutical Engineering,School of Chemical Engineering,Wuhan University of Technology
摘 要：Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation method and the mercaptopurine（MER） drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content（DLC）, encapsulation efficiency（EE） and delivery properties in vitro, determined by high performance liquid chromatograph（HPLC）. The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution（PBS） simulated body fluid, at 37 ℃ with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy.
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