Intracellular behaviour of samarium and europium in lactating mammary gland
来源期刊：JOURNAL OF RARE EARTHS2012年第3期
论文作者：Ayadi Ahlem Maghraoui Samira El Hili Ali Tekaya Leila
文章页码：274 - 277
摘 要：The subcellular localization of samarium and europium, two rare-earths, increasingly used in both medical and industrial fields, has been studied in several organs such as liver and kidney but never in the mammary gland despite of its importance in the biology of lactation and nutrition domains. The intracellular behaviour of samarium and europium after their intra-peritoneal administration in the lactating mammary gland cells was investigated. The results showed the presence of very electron dense deposits in the glandular epithelial cell lysosomes. These particular lysosomes were never observed in the mammary cell lysosomes of control rats. These intralysosomal deposits were probably composed of insoluble samarium or europium phosphates by analogy with previous studies, the transmission electron microscopy, the ion mass microscopy and the electron probe microanalysis, and other techniques allowing the identification of the chemical structure of the intralysosomal deposits.
Ayadi Ahlem1，Maghraoui Samira1，El Hili Ali2，Tekaya Leila1
1. Laboratoire de physiologie, Faculté de Médecine de Tunis. 15, rue Djebel lakhdhar. 1007 La Rabta. Tunis. Université Tunis El Manar, Tunisie2. Laboratoire de microscopie électronique, Faculté des Sciences de Tunis, Campus universitaire 2092, El Manar II, Tunis Université Tunis El Manar, Tunisie. Université Tunis El Manar Tunisie
摘 要：The subcellular localization of samarium and europium, two rare-earths, increasingly used in both medical and industrial fields, has been studied in several organs such as liver and kidney but never in the mammary gland despite of its importance in the biology of lactation and nutrition domains. The intracellular behaviour of samarium and europium after their intra-peritoneal administration in the lactating mammary gland cells was investigated. The results showed the presence of very electron dense deposits in the glandular epithelial cell lysosomes. These particular lysosomes were never observed in the mammary cell lysosomes of control rats. These intralysosomal deposits were probably composed of insoluble samarium or europium phosphates by analogy with previous studies, the transmission electron microscopy, the ion mass microscopy and the electron probe microanalysis, and other techniques allowing the identification of the chemical structure of the intralysosomal deposits.
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