Antibacterial Properties of Ti-6Al-4V-xCu Alloys
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2014年第7期
论文作者：Ling Ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang
文章页码：699 - 705
摘 要：Surgical implant-associated bacterial infection is becoming a serious clinical problem.A series of copper-bearing titanium alloy,Ti—6AI—4V—xCu（x = 1,3,5 wt%）,were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element.The metallography,X-ray diffraction,antibacterial ability,corrosion resistance and cytotoxicity of Ti—6AI—4V—xCu alloys were preliminarily studied with comparison to the commercial medical Ti—6AI—4V alloy.The Ti—6AI—4V—xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility,and the antibacterial role was enhanced with increasing Cu content,which has significant potential for clinical applications as surgical implant materials.
Ling Ren1，Zheng Ma1，Mei Li2，Yu Zhang2，Weiqiang Liu3，Zhenhua Liao3，Ke Yang1
1. Institute of Metal Research,Chinese Academy of Sciences2. Department of Orthopedic Surgery,Guangzhou General Hospital of Guangzhou Military Command3. Research Institute of Tsinghua University in Shenzhen,Shenzhen High-Tech Industrial Estate
摘 要：Surgical implant-associated bacterial infection is becoming a serious clinical problem.A series of copper-bearing titanium alloy,Ti—6AI—4V—xCu（x = 1,3,5 wt%）,were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element.The metallography,X-ray diffraction,antibacterial ability,corrosion resistance and cytotoxicity of Ti—6AI—4V—xCu alloys were preliminarily studied with comparison to the commercial medical Ti—6AI—4V alloy.The Ti—6AI—4V—xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility,and the antibacterial role was enhanced with increasing Cu content,which has significant potential for clinical applications as surgical implant materials.
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