Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2018年第6期
论文作者：Xiaoheng Guo Xiao Liu Huichang Gao Xuetao Shi Naru Zhao Yingjun Wang
文章页码：1054 - 1059
摘 要：In this study, we developed a simple approach for the controllable growth of whitlockite（WH） on a β-tricalcium phosphate surface and investigated its cell viability via CCK-8, its live-dead staining and its alkaline phosphatase activity. Herein, WH with controllable morphologies was prepared by regulating the hydrothermal reaction conditions. The results of scanning electron microscopy, X-ray diffraction and Xray photoelectron spectroscopy indicated that pure hexagonal plates of WH were prepared successfully.In vitro cell experiments showed that WH possessed excellent biocompatibility and effectively promoted the adhesion and proliferation of mouse bone mesenchymal stem cells. The osteogenesis of the WH was also enhanced. The obtained WH was expected to be utilized for promising applications as implantable block materials for bone repair.
Xiaoheng Guo1,2，Xiao Liu1,2，Huichang Gao3，Xuetao Shi1,2，Naru Zhao1,4，Yingjun Wang1,2
1. School of Materials Science and Engineering, South China University of Technology2. National Engineering Research Centre for Tissue Restoration and Reconstruction3. School of Medicine, South China University of Technology4. Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology
摘 要：In this study, we developed a simple approach for the controllable growth of whitlockite（WH） on a β-tricalcium phosphate surface and investigated its cell viability via CCK-8, its live-dead staining and its alkaline phosphatase activity. Herein, WH with controllable morphologies was prepared by regulating the hydrothermal reaction conditions. The results of scanning electron microscopy, X-ray diffraction and Xray photoelectron spectroscopy indicated that pure hexagonal plates of WH were prepared successfully.In vitro cell experiments showed that WH possessed excellent biocompatibility and effectively promoted the adhesion and proliferation of mouse bone mesenchymal stem cells. The osteogenesis of the WH was also enhanced. The obtained WH was expected to be utilized for promising applications as implantable block materials for bone repair.
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