Enhancement of the Pore Interconnectivity and Porosity of Calcium Phosphate Scaffolds by Acid-Etching Method
来源期刊：Acta Metallurgica Sinica2015年第9期
论文作者：Sujeong Lee Soyoung Yang Indu Bajpai Inn-Kyu Kang Sukyoung Kim
文章页码：1109 - 1116
摘 要：Porous hydroxyapatite（HA）–tricalcium phosphate（TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates（DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity,the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity（85%） was observed in the Ca-P scaffold with the lowest HA（7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content（85%）. X-ray diffraction showed that the extent of the b-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores,which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and nonetched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.
Sujeong Lee1，Soyoung Yang1，Indu Bajpai1，Inn-Kyu Kang2，Sukyoung Kim1
1. Materials Science and Engineering, Yeungnam University2. Department of Polymer Science and Engineering,Kyungpook National University
摘 要：Porous hydroxyapatite（HA）–tricalcium phosphate（TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates（DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity,the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity（85%） was observed in the Ca-P scaffold with the lowest HA（7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content（85%）. X-ray diffraction showed that the extent of the b-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores,which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and nonetched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.
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