Anti-biofilm Effect of Glass Ionomer Cements Incorporated with Chlorhexidine and Bioactive Glass
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2012年第2期
论文作者：黄雪清 黄翠
文章页码：270 - 275
摘 要：The effect of glass ionomer cement and resin-modified glass ionomer cement incorporated with chlorhexidine and bioactive glass on antimicrobial activity and physicochemical properties were investigated.The experimental results showed that groups incorporated with 1% chlorhexidine exhibited a significant reduction of optical density values of the bacterial suspension and increased the degradation of Streptococcus mutans biofilm.However,groups incorporated with 10% bioactive glass did not affect the optical density values and the biofilm formation.The mechanical properties of the materials and the polymerization were not influenced by the addition of chlorhexidine.Nevertheless,the compressive strength was lower when the materials were incorporated with bioactive glass.It can be concluded that glass ionomer cements incorporated with chlorhexidine can maintain its mechanical properties as well as reduce early S mutans biofilm formation.Controlled release/sustained release technology may be required to optimize the antibacterial activity of glass ionomer cements incorporated with bioactive glass.
黄雪清1,2，黄翠1
1. The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)& Key Laboratory of Oral Biomedicine Ministry of Education,School & Hospital of Stomatology,Wuhan University2. Department of Prosthodontics,Guanghua School and Hospital of Stomatology and Institute of Stomatological Research,Sun Yat-sen University
摘 要：The effect of glass ionomer cement and resin-modified glass ionomer cement incorporated with chlorhexidine and bioactive glass on antimicrobial activity and physicochemical properties were investigated.The experimental results showed that groups incorporated with 1% chlorhexidine exhibited a significant reduction of optical density values of the bacterial suspension and increased the degradation of Streptococcus mutans biofilm.However,groups incorporated with 10% bioactive glass did not affect the optical density values and the biofilm formation.The mechanical properties of the materials and the polymerization were not influenced by the addition of chlorhexidine.Nevertheless,the compressive strength was lower when the materials were incorporated with bioactive glass.It can be concluded that glass ionomer cements incorporated with chlorhexidine can maintain its mechanical properties as well as reduce early S mutans biofilm formation.Controlled release/sustained release technology may be required to optimize the antibacterial activity of glass ionomer cements incorporated with bioactive glass.
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