Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line
来源期刊：JOURNAL OF RARE EARTHS2004年第2期
论文作者：欧阳砥 申泮文 牛瑞芳 李瑾 周永洽 胡国武
Key words：cytobiology; cerium; matrix metalloproteinases; malignant tumor; metastasis; rare earths;
Abstract: The effects of Ce4+ on cell survival,expression and activity of matrix metalloproteinase-9(MMP-9)with MTT colorimetry and gelatin zymography assays in human bladder carcinoma cell line was studied.The results indicate that the lower concentration of Ce4+(0.01 mmol*L-1)has no influence on cell growth,but inhibits extremely expression of MMP-9 and increases its activity,whereas the higher concentration of Ce4+(1.0 mmol*L-1)can inhibit all of them.The results raise the possibility that Ce4+ may have beneficial effects in attenuating invasion and metastasis of malignant tumors.
欧阳砥1，申泮文1，牛瑞芳2，李瑾1，周永洽1，胡国武1
(1.Department of Chemistry,Nankai University,Tianjin 300071,China;
2.Central Laboratory,Tianjin Cancer Hospital,Tianjin 300060,China)
Abstract:The effects of Ce4+ on cell survival,expression and activity of matrix metalloproteinase-9(MMP-9)with MTT colorimetry and gelatin zymography assays in human bladder carcinoma cell line was studied.The results indicate that the lower concentration of Ce4+(0.01 mmol*L-1)has no influence on cell growth,but inhibits extremely expression of MMP-9 and increases its activity,whereas the higher concentration of Ce4+(1.0 mmol*L-1)can inhibit all of them.The results raise the possibility that Ce4+ may have beneficial effects in attenuating invasion and metastasis of malignant tumors.
Key words:cytobiology; cerium; matrix metalloproteinases; malignant tumor; metastasis; rare earths;
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