Preparation and Characterization of an Intelligent Multitarget Tracking HA-RGD-CLB-QDs Drug Delivery System
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2017年第6期
论文作者：吴峰政 徐海星 ZHU Zhihua LI Xin Lü Yahui MA Tian CAI Xinjie LI Rui 许沛虎
文章页码：1493 - 1502
摘 要：This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGDchlorambucil-quantum dots（HA-RGD-CLB-QDs） drug delivery system. After deacetylated, hyaluronic acid was reacted with anticancer drug chlorambucil, RGD, and quantum dots to obtain the HA-RGD-CLB-QDs drug delivery system. The characterization by FT-IR, 1 H NMR, TEM, XPS, DLS, and UV-vis absorption and fluorescence spectra show that the system is successfully constructed with an average particle size of about 70 nm. The results of the drug release profile show that that the system has a p H and enzyme sensitive controlled release behaviour. Moreover, cellular uptake and toxicity results show that the system has an ideal dual receptormediated endocytosis pathway that significantly enhances the efficacy of CLB tumor therapy and has a lower toxicity to normal cells.The system shows the potential application as a carrier for cancer therapy.
吴峰政1，徐海星1，ZHU Zhihua2，LI Xin1，Lü Yahui1，MA Tian1，CAI Xinjie1，LI Rui1，许沛虎1
1. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology2. Wuhan Science and Technology Bureau
摘 要：This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGDchlorambucil-quantum dots（HA-RGD-CLB-QDs） drug delivery system. After deacetylated, hyaluronic acid was reacted with anticancer drug chlorambucil, RGD, and quantum dots to obtain the HA-RGD-CLB-QDs drug delivery system. The characterization by FT-IR, 1 H NMR, TEM, XPS, DLS, and UV-vis absorption and fluorescence spectra show that the system is successfully constructed with an average particle size of about 70 nm. The results of the drug release profile show that that the system has a p H and enzyme sensitive controlled release behaviour. Moreover, cellular uptake and toxicity results show that the system has an ideal dual receptormediated endocytosis pathway that significantly enhances the efficacy of CLB tumor therapy and has a lower toxicity to normal cells.The system shows the potential application as a carrier for cancer therapy.
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