Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

王守霞¹，胡执一¹，HU Jie¹，QIU Zhiming²，李俊丽¹，GENG Wei^1,3,4，SU Baolian^1,5，阳晓宇^1,3,4,6

1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering,School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology2. School of Materials Science and Technology, South China University of Technology3. School of Chemical Engineering and Technology, Sun Yat-sen University4. China & Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)5. Laboratory of Inorganic Materials Chemistry (CMI), University of Namur6. School of Engineering and Applied Sciences, Harvard University

摘 要：We have developed a controlled-release drug carrier.Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core.The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy （¹H-NMR）,scanning electron microscope （SEM） and X-ray spectroscopy （EDX）.Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell.The mesoporous shell was characterized by transmission electron microscopy （TEM） and scanning electron microscope （SEM）.All the results showed that a well-defined core-shell structure with mesoporous structure was obtained,and this controllable delivery system will have the great potential in nanomedicine.

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