Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo（ethylene glycol）-amino Mixed Self-assembled Monolayers
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2016年第9期
论文作者：Lijing Hao Tianjie Li Naru Zhao Fuzhai Cui Chang Du Yingjun Wang
文章页码：966 - 970
摘 要：Oligo（ethylene glycol）（-OEG） and amino（-NH2） mixed self-assembled monolayers（SAMs） were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells（MSCs） and osteopontin（OPN） adsorption. We found that all surfaces presenting-NH2 groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge.
Lijing Hao1,2，Tianjie Li1,2，Naru Zhao1,2，Fuzhai Cui3，Chang Du1,2，Yingjun Wang1,2
1. School of Materials Science and Engineering, South China University of Technology2. National Engineering Research Center for Tissue Restoration and Reconstruction3. Department of Materials Science and Engineering, Tsinghua University
摘 要：Oligo（ethylene glycol）（-OEG） and amino（-NH2） mixed self-assembled monolayers（SAMs） were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells（MSCs） and osteopontin（OPN） adsorption. We found that all surfaces presenting-NH2 groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge.
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