In vitro corrosion behavior and cytotoxicity property of magnesium matrix composite with chitosan coating
来源期刊：中南大学学报(英文版)2015年第3期
论文作者：DAI Yi-long(戴翌龙) YU Kun(余琨) CHEN Liang-jian(陈良建) CHEN Chang(陈畅) 乔雪岩 YAN Yang(颜阳)
文章页码：829 - 834
Key words：magnesium matrix composite; chitosan coating; in vitro test; cytotoxicity
Abstract: Mg-6%Zn-10%β-Ca3(PO4)2 composite was prepared through powder metallurgy methods with different chitosan coatings on its surface. The properties of the chitosan coatings on the surface of Mg-6%Zn-10%β-Ca3(PO4)2 composite, such as the adhesion ability, the corrosion behavior and the cytotoxicity properties, were investigated, and the microstructure of the chitosan coating was observed by scanning electron microscope (SEM). The results show that chitosan coating improves the corrosion resistance of the magnesium composite specimens significantly. Mg-6%Zn-10%β-Ca3(PO4)2 composite specimens exhibit good corrosion resistance and low pH values in simulated body fluid (SBF) at 37 °C in the immersion test with 7-layer chitosan coating whose relative molecular mass is 30×104 Da. The cytotoxicity tests indicate that Mg-6%Zn-10%β-Ca3(PO4)2 with chitosan coating is nontoxic with a cytotoxicity grade of zero against L-929 cells, which is better than that of uncoated composites.
DAI Yi-long(戴翌龙)1, YU Kun(余琨)1, 2, CHEN Liang-jian(陈良建)2, 3, CHEN Chang(陈畅)2, QIAO Xue-yan(乔雪岩)1, YAN Yang(颜阳)1
(1. School of Materials Science and Engineering, Central South University, Changsha 410083, China;
2. State Key Laboratory of Powder Metallurgy (Central South University), Changsha 410083, China;
3. XiangYa Third Hospital, Central South University, Changsha 410013, China)
Abstract:Mg-6%Zn-10%β-Ca3(PO4)2 composite was prepared through powder metallurgy methods with different chitosan coatings on its surface. The properties of the chitosan coatings on the surface of Mg-6%Zn-10%β-Ca3(PO4)2 composite, such as the adhesion ability, the corrosion behavior and the cytotoxicity properties, were investigated, and the microstructure of the chitosan coating was observed by scanning electron microscope (SEM). The results show that chitosan coating improves the corrosion resistance of the magnesium composite specimens significantly. Mg-6%Zn-10%β-Ca3(PO4)2 composite specimens exhibit good corrosion resistance and low pH values in simulated body fluid (SBF) at 37 °C in the immersion test with 7-layer chitosan coating whose relative molecular mass is 30×104 Da. The cytotoxicity tests indicate that Mg-6%Zn-10%β-Ca3(PO4)2 with chitosan coating is nontoxic with a cytotoxicity grade of zero against L-929 cells, which is better than that of uncoated composites.
Key words:magnesium matrix composite; chitosan coating; in vitro test; cytotoxicity
