Synthesis, characterization, and biological properties of nano-rare earth complexes with L-glutamic acid and imidazole
来源期刊：Journal of Rare Earths2008年第4期
论文作者：周美锋 何其庄
文章页码：473 - 477
摘 要：Four nano-rare earth ternary complexes of L-glutamic acid and imidazole RE（Glu）3ImCl3·3H2O （RE=Ce3+, Pr3+, Sm3+, Dy3+, Glu= L-glutamic acid , and Im=imidazole） were synthesized. Their composition was characterized with elemental analysis, IR, and molar conductance. The TEM image indicated that the complexes were regular shaped and the length was about 3060 nm. The antibacterial activity test showed that all these complexes exhibited better antibacterial ability against Escherichia coli, Staphylociccus aureus, and Candida albican （MIC were about 180, 100, and 310 μg/ml, respectively） and could be considered as broad-spectral antimicrobial. Their antitumor activity in vitro against leukemia K562 cells was measured using the MTT method. The results indicate that the four complexes possess strong inhibi- tion effect on leukemia K562 cells. An approximately linear relationship is discovered between the relative inhibition rate and concentration, with the correlation coefficients R>0.7 and P<0.05, which is considered statistically significant.
周美锋，何其庄
摘 要：Four nano-rare earth ternary complexes of L-glutamic acid and imidazole RE（Glu）3ImCl3·3H2O （RE=Ce3+, Pr3+, Sm3+, Dy3+, Glu= L-glutamic acid , and Im=imidazole） were synthesized. Their composition was characterized with elemental analysis, IR, and molar conductance. The TEM image indicated that the complexes were regular shaped and the length was about 3060 nm. The antibacterial activity test showed that all these complexes exhibited better antibacterial ability against Escherichia coli, Staphylociccus aureus, and Candida albican （MIC were about 180, 100, and 310 μg/ml, respectively） and could be considered as broad-spectral antimicrobial. Their antitumor activity in vitro against leukemia K562 cells was measured using the MTT method. The results indicate that the four complexes possess strong inhibi- tion effect on leukemia K562 cells. An approximately linear relationship is discovered between the relative inhibition rate and concentration, with the correlation coefficients R>0.7 and P<0.05, which is considered statistically significant.
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