Synthesis and anticancer properties of tungstosilicic polyoxometalate containing 5-fluorouracil and neodymium
来源期刊：JOURNAL OF RARE EARTHS2010年第6期
论文作者：刘霞 王帅帅 冯长根
文章页码：965 - 968
摘 要：A novel tungstosilicic polyoxometalate containing 5-fluorouracil and Nd, K26（C4H4FN2O2）8Nd（SiW11O39）4·5H2O （FNSW） was synthesized and its structure was characterized by using elemental analysis, FT-IR spectra, X-ray powder diffraction, UV-vis spectra and TG. The results indicated that the compound FNSW had Keggin structure of heteropolyanion and ring structure of 5-fluorouracil, and it had a good thermal stability. With 5-fluorouracil for the positive control group, the cytotoxicity tests in human renal embryonic cell HEK293 and the antitumor activity tests in hepatocellular carcinoma cell HepG-2 were carried out by the methyl thiazolyl tetrazolium method. The toxicity of the compound FNSW was lower than that of 5-fluorouracil, and compared with 5-fluorouracil the compound FNSW could inhibit HepG-2 cell in vitro with significant difference. The rare earth element Nd increased the biological activity of polyoxometalate significantly.
刘霞1，王帅帅2，冯长根2
1. College of Science, China Agricultural University2. State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology
摘 要：A novel tungstosilicic polyoxometalate containing 5-fluorouracil and Nd, K26（C4H4FN2O2）8Nd（SiW11O39）4·5H2O （FNSW） was synthesized and its structure was characterized by using elemental analysis, FT-IR spectra, X-ray powder diffraction, UV-vis spectra and TG. The results indicated that the compound FNSW had Keggin structure of heteropolyanion and ring structure of 5-fluorouracil, and it had a good thermal stability. With 5-fluorouracil for the positive control group, the cytotoxicity tests in human renal embryonic cell HEK293 and the antitumor activity tests in hepatocellular carcinoma cell HepG-2 were carried out by the methyl thiazolyl tetrazolium method. The toxicity of the compound FNSW was lower than that of 5-fluorouracil, and compared with 5-fluorouracil the compound FNSW could inhibit HepG-2 cell in vitro with significant difference. The rare earth element Nd increased the biological activity of polyoxometalate significantly.
关键词：
