Synthesis and Characterization of Carboxyl-terminated Polyethylene Glycol Functionalized Mesoporous Silica Nanoparticles
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2018年第6期
论文作者：王瑜 WANG Youyun WANG Wanxia ZHU Hongda 刘明星
文章页码：1540 - 1545
摘 要：Colloidal mesoporous silica nanoparticles functionalized with carboxy-terminated polyethylene glycol（CMS-PEG-COOH） were successfully synthesized by covalently grafting dicarboxy-terminated polyethylene glycol（HOOC-PEG-COOH） on the surface of the amino functionalized CMS nanoparticles with amide bond as a cross linker. Moreover, the structural and particle properties of CMS-PEG-COOH were characterized by nuclear magnetic resonance spectroscopy（1 H-NMR）, transmission electron microscopy（TEM）, dynamic light scattering（DLS）, nitrogen adsorption-desorption measurements, X-ray diffraction（XRD）, and Fourier transform infrared spectroscopy（FT-IR）. The nanomaterials presented a relatively uniform spherical shape morphology with diameters of about 120 nm,and favorable dispersibility in weak acid solution. The CMSPEG-COOH exhibited no changes in the state of amorphous, while the mesopores sizes of 5.25 nm might provide the nanomaterials with large capacity for the loading and releasing of drugs. So the results indicated that CMSPEG-COOH might be a critical nanomaterial for drug delivery system in the future.
王瑜，WANG Youyun，WANG Wanxia，ZHU Hongda，刘明星
Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology,Hubei University of Technology
摘 要：Colloidal mesoporous silica nanoparticles functionalized with carboxy-terminated polyethylene glycol（CMS-PEG-COOH） were successfully synthesized by covalently grafting dicarboxy-terminated polyethylene glycol（HOOC-PEG-COOH） on the surface of the amino functionalized CMS nanoparticles with amide bond as a cross linker. Moreover, the structural and particle properties of CMS-PEG-COOH were characterized by nuclear magnetic resonance spectroscopy（1 H-NMR）, transmission electron microscopy（TEM）, dynamic light scattering（DLS）, nitrogen adsorption-desorption measurements, X-ray diffraction（XRD）, and Fourier transform infrared spectroscopy（FT-IR）. The nanomaterials presented a relatively uniform spherical shape morphology with diameters of about 120 nm,and favorable dispersibility in weak acid solution. The CMSPEG-COOH exhibited no changes in the state of amorphous, while the mesopores sizes of 5.25 nm might provide the nanomaterials with large capacity for the loading and releasing of drugs. So the results indicated that CMSPEG-COOH might be a critical nanomaterial for drug delivery system in the future.
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