Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid

来源期刊：中南大学学报(英文版)2003年第1期

论文作者：唐课文 周春山

文章页码：44 - 48

Key words：L-dibenzoyltartaric acid; terbutaline enantiomers; chiral extraction

Abstract: Distribution behavior of terbutaline enantiomers was examined in the aqueous and organic solvent of a two-phase system containing L-dibenzoyltartaric acid and lipophilic phase transfer reagent of Na-tetraphenylborate. The influences of pH, organic solvents, concentrations of Na-tetraphenyl-borate and L-dibenzoyltartaric acid on the partition coefficients and enantioselectivity of terbutaline enantiomers, were investigated. The results show that tetraphenylborate lipophilic anion and terbutaline enantiomers form two lipophilic salt complexes ,which facilitates the solubility of the enantiomers in the organic phase. L-dibenzoyltartaric acid forms more stable complexes with enantiomerⅡthan with enantiomerⅠ. Enantioselectivity and partition coefficient increase with the addition of the length of alkyl chain of alcohols. pH and concentrations of lipophilic anion and L-dibenzoyltartaric acid influence them obviously and differently.