Cell Growth and Desorption on the Surface of Temperature-sensitive Semi-IPNs Hydrogels Based on Silk Sericin
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2012年第5期
论文作者：李学伟 陈莉
文章页码：907 - 910
摘 要：Semi-interpenetrating （semi-IPNs） hydrogels containing biocompatible silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAM） were prepared as novel cellular matrices. Their maximum swelling degree and basic characteristics for biomedical applications such as mouse ?broblasts （L929） cell proliferation and desorption were investigated. The results showed that the incorporation of high hydrophilic SS into PNIPAM hydrogel increased the maximum swelling degree of the semi-IPNs hydrogels, and the adhesion and growth of the L929 on semi-IPNs hydrogels were at least comparable to, or even better than, that on conventional PNIPAM hydrogel. In addition, L929 cells were found to detach from the hydrogels surface naturally by controlling environmental temperature. These results suggest great potential of semi-IPNs hydrogels in tissue engineering.
李学伟1,2，陈莉1
1. State Key Laboratory of Hollow Fiber Membrane Materials and Processes,School of Materials Science and Engineering,TianjinPolytechnic University2. Chongqing Academy of Metrology and Quality Inspection
摘 要：Semi-interpenetrating （semi-IPNs） hydrogels containing biocompatible silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAM） were prepared as novel cellular matrices. Their maximum swelling degree and basic characteristics for biomedical applications such as mouse ?broblasts （L929） cell proliferation and desorption were investigated. The results showed that the incorporation of high hydrophilic SS into PNIPAM hydrogel increased the maximum swelling degree of the semi-IPNs hydrogels, and the adhesion and growth of the L929 on semi-IPNs hydrogels were at least comparable to, or even better than, that on conventional PNIPAM hydrogel. In addition, L929 cells were found to detach from the hydrogels surface naturally by controlling environmental temperature. These results suggest great potential of semi-IPNs hydrogels in tissue engineering.
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