Electrostatic assembly functionalization of poly（γ-glutamic acid） for biomedical antibacterial applications
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2020年第24期
论文作者：Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan
摘 要：Poly（γ-glutamic acid）（γ-PGA） has been found widespread applications in biomedical field because of its excellent water solubility, biocompatibility, and bioactivity. Herein, a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate（ELA）. The functionalized γ-PGA compound（γ-PGA-ELA） ethanol solution can facilely produce colorless and transparent coatings on various inorganic, metal, and polymeric substrates, especially for the lumen of slender catheters（length up to 2 m, and inner diameter down to 1 mm）. The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo. In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion, and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy. More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility, low cytotoxicity, and satisfactory histocompatibility. The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections.
Xiaodan Wang1,2，Hengchong Shi1，Haoyu Tang3，Huan Yu1,2，Qiuyan Yan1，Huawei Yang1，Xu Zhang1，Shifang Luan1,2
1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences2. University of Science and Technology of China3. Institute of Functional Nano & Soft Materials, Soochow University
摘 要：Poly（γ-glutamic acid）（γ-PGA） has been found widespread applications in biomedical field because of its excellent water solubility, biocompatibility, and bioactivity. Herein, a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate（ELA）. The functionalized γ-PGA compound（γ-PGA-ELA） ethanol solution can facilely produce colorless and transparent coatings on various inorganic, metal, and polymeric substrates, especially for the lumen of slender catheters（length up to 2 m, and inner diameter down to 1 mm）. The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo. In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion, and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy. More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility, low cytotoxicity, and satisfactory histocompatibility. The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections.
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