Ultra-small MoS2 nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2021年第4期
论文作者：Leilei Chen Jun Xu Yi Wang Rongqin Huang
摘 要：Functionalization of mesoporous silica spheres with well-dispersed and ultra-small nanodots to exert their synergistic effects for biomedical applications has been considered to be an urgent challenge. Herein,homogeneously incorporation of ultra-small and monodispersed MoS2 nanodots in the mesoporous silica nanospheres（MSN） was achieved by a facile one-step solvothermal reaction. The as-synthesized UsMSND@MSN possessed uniform size（～115 nm） and favorable biocompatibility inherited from MSN. The dispersed UsMSND within MSN could act as anchoring sites for aromatic anti-cancer drug DOX loading,and consequently achieved pH-responsive release based on the special π-π/electrostatic interactions with the DOX molecules. More importantly, the well-dispersed UsMSND in MSN could function as the non-toxic contrast agent for the sensitive in vivo CT imaging in various tumors including breast cancer and glioma with different sections. This work promises a good strategy for dispersed incorporation of UsMSND into MSN as an excellent pH-responsive platform for simultaneous cancer imaging and therapy.
Leilei Chen1，Jun Xu2，Yi Wang1，Rongqin Huang3
1. Center for Advanced Low-dimension Materials, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry,Chemical Engineering and Biotechnology, Donghua University2. Department of Orthopaedics, Minhang Hospital, Fudan University3. Minhang Hospital and School of Pharmacy, Fudan University
摘 要：Functionalization of mesoporous silica spheres with well-dispersed and ultra-small nanodots to exert their synergistic effects for biomedical applications has been considered to be an urgent challenge. Herein,homogeneously incorporation of ultra-small and monodispersed MoS2 nanodots in the mesoporous silica nanospheres（MSN） was achieved by a facile one-step solvothermal reaction. The as-synthesized UsMSND@MSN possessed uniform size（～115 nm） and favorable biocompatibility inherited from MSN. The dispersed UsMSND within MSN could act as anchoring sites for aromatic anti-cancer drug DOX loading,and consequently achieved pH-responsive release based on the special π-π/electrostatic interactions with the DOX molecules. More importantly, the well-dispersed UsMSND in MSN could function as the non-toxic contrast agent for the sensitive in vivo CT imaging in various tumors including breast cancer and glioma with different sections. This work promises a good strategy for dispersed incorporation of UsMSND into MSN as an excellent pH-responsive platform for simultaneous cancer imaging and therapy.
关键词：
