导向药物用纳米Fe₃O₄磁性粒子的制备及表征

来源期刊：中南大学学报(自然科学版)2003年第5期

论文作者：蒋新宇 周春山 张俊山 杨娟玉

文章页码：516 - 520

关键词：导向药物; Fe₃O₄磁性粒子;表面活性剂

Key words：targeted-drug; Fe₃O₄ magnetic particles; surfactant

摘    要：采用化学共沉淀法先生成Fe₃O₄微粒,再将其分散于含有表面活性剂的水中的方法制备了纳米级Fe₃O₄磁性粒子.通过双层表面活性剂包覆可使Fe₃O₄磁性粒子稳定分散于水中而不聚集.在反应溶液pH值为11~12,温度为60℃及油酸钠为第1层表面活性剂,十二烷基苯磺酸钠为第2层表面活性剂的条件下制备了粒径为36 nm的Fe₃O₄磁性粒子.实验结果表明:反应溶液pH值和表面活性剂是影响Fe₃O₄磁性粒子稳定性、粒径和饱和磁化强度的主要因素;利用XRD和IR证实了Fe3O4磁性粒子中存在Fe₃O₄和表面活性剂结构.所制备的纳米级Fe₃O₄磁性粒子可用作导向药物的磁载体.

Abstract: Fe₃O₄ magnetic nanoparticles are synthesized by a sequential process involving the chemical coprecipitation of Fe²⁺and Fe³⁺salts with sodium hydroxide(NaOH) followed by resuspension of the ultrafine particles in water using surfactant. This procedure produces nanoparticles stabilized against agglomeration by bilayers of surfactant encapsulating the nanoparticles. Experiment results indicate that pH value of the reactive solution, surfactant have great effects on the stability, size and saturation magnetic intensity of the Fe₃O₄ magnetic particles. Under the conditions of pH11~12, 60℃and sodium oleate as the primary surfactant, sodium dodecyl benzene sulfonate as the secondary surfactant, Fe₃O₄ magnetic particles with a size of 36 nm and higher saturation magnetic intensity are obtained. XRD and IR analysis measurement results show the existence of Fe₃O₄ and surfactant structure. The Fe₃O₄ magnetic particles can be used as targeted-drug carriers.