Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2021年第9期
论文作者：Mingjun Li Christoph Schlaich Jianguang Zhang Ievgen S.Donskyi Karin Schwibbert Frank Schreiber Yi Xia J?rg Radnik Tanja Schwerdtle Rainer Haag
文章页码：160 - 171
摘 要：Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles（Cu NPs） were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol（MI-h PG） coating via a simple dip-coating method.This hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone（PCL） electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-（MI-h PG）-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus（S. aureus）, Escherichia coli（E. coli）, and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-（MI-h PG）-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs.
Mingjun Li1,2，Christoph Schlaich2，Jianguang Zhang2，Ievgen S.Donskyi2,3，Karin Schwibbert4，Frank Schreiber4，Yi Xia2，J?rg Radnik3，Tanja Schwerdtle5，Rainer Haag2
1. Center for Health Science and Engineering, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology2. Institut für Chemie und Biochemie, Freie Universit?t Berlin3. Division of Surface Analysis and Interfacial Chemistry, Federal Institute for Materials Research and Testing (BAM)4. Division Biodeterioration and Reference Organisms, Federal Institute for Materials Research and Testing(BAM)5. Institute of Nutritional Science, Department of Food Chemistry, University of Potsdam
摘 要：Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles（Cu NPs） were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol（MI-h PG） coating via a simple dip-coating method.This hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone（PCL） electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-（MI-h PG）-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus（S. aureus）, Escherichia coli（E. coli）, and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-（MI-h PG）-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs.
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