An in-vitro Investigation of Iron-Containing Hydroxyapatite/Titanium Composites

Q.Chang1,2),H.Q.Ru1),D.L.Chen2),X.Y.Yue1),L.Yu1) and C.P.Zhang1) 1) Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education),Northeastern University,Shenyang 110004,China 2) Department of Mechanical and Industrial Engineering,Ryerson University,350 Victoria Street,Toronto,Ontario M5B 2K3,Canada

摘 要：The in-vitro biological behavior of a newly-developed iron-containing hydroxyapatite/titanium（HA/Ti） composite was investigated by immersing the composites in the simulated body fluid（SBF） for up to 5 weeks.The addition of iron was observed to have a significant influence on the in-vitro biological behavior of the composites.The obtained results revealed that the stability of the composites in the physiological solution was markedly improved.The solubility decreased in the order of pure HA,HA/5（Ti-33Fe）,and HA/15（Ti33Fe）.Precipitation occurred on the surface of HA/5（Ti-33Fe） composite,showing a good combination of physiostability with bioactivity,while HA/15（Ti-33Fe） composite exhibited superior physiostability since there was no obvious change on the surface of HA/15（Ti-33Fe）.

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