In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application
来源期刊：中国有色金属学报(英文版)2011年第z2期
论文作者：SUN Yu KONG Min-xiu JIAO Xiao-hui
文章页码：252 - 257
Key words：magnesium alloy; biodegradation; biocompatibility; cytotoxicity
Abstract: The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.
SUN Yu1, KONG Min-xiu2, JIAO Xiao-hui1
(1. Stomatology Hospital, Harbin Medical University, Harbin 150001, China;
2. State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150080, China)
Abstract:The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.
Key words:magnesium alloy; biodegradation; biocompatibility; cytotoxicity
