Binary Zn–Ti alloys for orthopedic applications: Corrosion and degradation behaviors, friction and wear performance, and cytotoxicity
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2021年第15期
论文作者：Kun Wang Xian Tong Jixing Lin Aiping Wei Yuncang Li Matthew Dargusch Cuie Wen
摘 要：Zinc（Zn） and its biocompatible and biodegradable alloys have substantial potential for use in orthopedic implants. Nevertheless, pure Zn with a hexagonal close-packed crystal structure has only two independent slip systems, therefore exhibiting extremely low elongation and yield strength in its ascast condition, which restricts its clinical applications. In this study, as-cast Zn–xTi（titanium）（x = 0.05,0.10, 0.20, and 0.30 wt.%） binary alloys were hot-rolled and their microstructures, mechanical properties, wear resistance, and cytocompatibility were comprehensively investigated for orthopedic implant applications. The microstructures of both as-cast and hot-rolled Zn–xTi alloys consisted of an α-Zn matrix phase and a TiZn16 phase, while Zn–0.2 Ti and Zn–0.3 Ti exhibited a finer α-Zn phase due to the grainrefining effect of Ti. The hot-rolled Zn–0.2 Ti alloy exhibited the highest yield strength（144.5 MPa）,ultimate strength（218.7 MPa）, and elongation（54.2%） among all the Zn–x Ti alloys. The corrosion resistance of Zn–xTi alloys in Hanks’ solution decreased with increasing addition of Ti, and the hot-rolled Zn–0.3 Ti alloy exhibited the highest corrosion rates of 432 μm/y as measured by electrochemical testing and 57.9 μm/y as measured by immersion testing. The as-cast Zn–xTi alloys showed lower wear losses than their hot-rolled counterparts. The extracts of hot-rolled Zn–x Ti alloys at concentrations of ≤ 25%showed no cytotoxicity to MG-63 osteosarcoma cells and the extracts of Zn–xTi alloys exhibited enhanced cytocompatibility with increasing Ti content.
Kun Wang1,2，Xian Tong3,1，Jixing Lin1，Aiping Wei1，Yuncang Li4，Matthew Dargusch5，Cuie Wen4
1. Department of Material Engineering, Zhejiang Industry & Trade Vocational College2. Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences Heifei3. School of Materials Science and Engineering, Xiangtan University4. School of Engineering, RMIT University5. Centre for Advanced Materials Processing and Manufacturing (AMPAM), The University of Queensland
摘 要：Zinc（Zn） and its biocompatible and biodegradable alloys have substantial potential for use in orthopedic implants. Nevertheless, pure Zn with a hexagonal close-packed crystal structure has only two independent slip systems, therefore exhibiting extremely low elongation and yield strength in its ascast condition, which restricts its clinical applications. In this study, as-cast Zn–xTi（titanium）（x = 0.05,0.10, 0.20, and 0.30 wt.%） binary alloys were hot-rolled and their microstructures, mechanical properties, wear resistance, and cytocompatibility were comprehensively investigated for orthopedic implant applications. The microstructures of both as-cast and hot-rolled Zn–xTi alloys consisted of an α-Zn matrix phase and a TiZn16 phase, while Zn–0.2 Ti and Zn–0.3 Ti exhibited a finer α-Zn phase due to the grainrefining effect of Ti. The hot-rolled Zn–0.2 Ti alloy exhibited the highest yield strength（144.5 MPa）,ultimate strength（218.7 MPa）, and elongation（54.2%） among all the Zn–x Ti alloys. The corrosion resistance of Zn–xTi alloys in Hanks’ solution decreased with increasing addition of Ti, and the hot-rolled Zn–0.3 Ti alloy exhibited the highest corrosion rates of 432 μm/y as measured by electrochemical testing and 57.9 μm/y as measured by immersion testing. The as-cast Zn–xTi alloys showed lower wear losses than their hot-rolled counterparts. The extracts of hot-rolled Zn–x Ti alloys at concentrations of ≤ 25%showed no cytotoxicity to MG-63 osteosarcoma cells and the extracts of Zn–xTi alloys exhibited enhanced cytocompatibility with increasing Ti content.
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