An impedance response model for inhibitory effect of antibiotics on bacterial growth in biometallurgy
来源期刊：中国有色金属学报(英文版)2004年第3期
论文作者：陶菡 魏万之 张书芬 张进忠 毛友安
文章页码：603 - 608
Key words：impedance response model; Logistics popular growth model; inhibitory parameters ; taphylococcus aureus; antibiotics
Abstract: An impedance response model reflecting the inhibitory effect of antibiotics on bacterial growth in biometallurgy was established. Three inhibition parameters, i.e. the maximum amount inhibitory constant of the bacterial growth (K1), the maximum specific growth inhibitory constant(K2) and the lag time inhibitory constant(K3), were included in the model. The influence of these parameters on the response curve was discussed in detail. By fitting experimental data towards the proposed model, three growth parameters (A,μm and λ) in the presence of antibiotics were gained and compared. The results show that the growth ability of bacteria is decreased due to the influence of antibiotics. The experimental and fitted curves have goodness-of-fit in the range of 0.987-1.008. Moreover, the kinetic growth parameters obtained from this model are closed to those from the Logistics popular growth model. These results show that the proposed model is validity to reflect the inhibitory effect of antibiotics on bacteria.
