EFFECT OF METAL IONS ON ACTIVITY OF INTERLEUKIN-2
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition1997年第4期
论文作者：孙恩杰
文章页码：58 - 62
摘 要：<正>1 IntrodutionInterleukin-2（IL-2）was found to selectively keep growth of T lymphocytes for longperiod in vitro in 1976,and was then named T cell growth factor,TCGF.After that,IL-2 was found to promote proliferation of various cells,mainly including T,B,NK,and to in-crease activity of T cell and NK cell.Discovery of its surprising effect in treatment of can-cer,tumor through inducing LAK（lymphokine-activated killer cells）or activating TIL（tumor infiltrated lymphocytes）to kill cancer cell made it very attractive.Therefore it wasfound a wide application in therapy of cancer,immunodeficiency and diseases relating toinfection.However,in its application,problem was found that it had very serious side-effect,and very high dose made the side effect even more serious.The aim of this study was to find a simple way to stabilize IL-2 so as to lower the doserequired in application and in turn to solve the problem.
孙恩杰
摘 要：<正>1 IntrodutionInterleukin-2（IL-2）was found to selectively keep growth of T lymphocytes for longperiod in vitro in 1976,and was then named T cell growth factor,TCGF.After that,IL-2 was found to promote proliferation of various cells,mainly including T,B,NK,and to in-crease activity of T cell and NK cell.Discovery of its surprising effect in treatment of can-cer,tumor through inducing LAK（lymphokine-activated killer cells）or activating TIL（tumor infiltrated lymphocytes）to kill cancer cell made it very attractive.Therefore it wasfound a wide application in therapy of cancer,immunodeficiency and diseases relating toinfection.However,in its application,problem was found that it had very serious side-effect,and very high dose made the side effect even more serious.The aim of this study was to find a simple way to stabilize IL-2 so as to lower the doserequired in application and in turn to solve the problem.
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