Effect of Long-Term Intake of Y3+ in Drinking Water on Gene Expression in Brains of Rats
来源期刊：JOURNAL OF RARE EARTHS2006年第3期
论文作者：Liu Jiesheng Xue Yanfang Yang Weidong Zhang Ping
Key words：gene expression; rats; cRNA; rare earths;
Abstract: The rats were fed with water dissolved Y3 + at different levels (0, 53.4, 5340 mg· L- 1 ) for 7 months. The gene expression in brain tissue was detected with oligonucleotide microarray. The results show that, compared to the control,789 genes express differentially, 507 over-expressed genes and 282 under-expressed genes in the high-dose group (5340found to express differentially including 32 over-expressed genes and 12 under-expressed genes in the low-dose group (53.sults suggest that Y3 + can change the expression of some genes, which may be responsible for the toxicity of rare earths on learning and memory.
Liu Jiesheng1，Xue Yanfang1，Yang Weidong1，Zhang Ping1
(1.Department of Biotechnology, Jinan University, Guangzhou 510632, China)
Abstract:The rats were fed with water dissolved Y3 + at different levels (0, 53.4, 5340 mg· L- 1 ) for 7 months. The gene expression in brain tissue was detected with oligonucleotide microarray. The results show that, compared to the control,789 genes express differentially, 507 over-expressed genes and 282 under-expressed genes in the high-dose group (5340found to express differentially including 32 over-expressed genes and 12 under-expressed genes in the low-dose group (53.sults suggest that Y3 + can change the expression of some genes, which may be responsible for the toxicity of rare earths on learning and memory.
Key words:gene expression; rats; cRNA; rare earths;
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