Synthesis of NaYF4:Yb,Er upconversion nanoparticle-based optomagnetic multifunctional composite for drug delivery system
来源期刊：JOURNAL OF RARE EARTHS2021年第5期
论文作者：Xuhua Liang Jun Fan Yanyan Zhao Ruyi Jin
文章页码：579 - 586
摘 要：Optomagnetic multifunctional composite has attracted much attention in recent years because of its promising application prospect in bioimaging,analysis,detection,disease diagnosis,and targeted drug delivery.To explore a dual-targeted therapy for cancer,a novel class of optomagnetic multifunctional composite（UCNP-Fe3 O4@MSNs-FA） was successfully synthesized by using upconversion nanoparticles（UCNPs） as nucleus,embedding Fe3 O4 nanoparticles into the SiO2 coating layer,and modifying the surface with folic acid（FA） to strengthen its tumor targeting performance.The properties of the composite were extensively studied.The obtained composite possesses excellent upconversion fluorescence,good dispersion,high specific surface area（229.347 m2/g）,and saturation magnetization value（10.9 A m2/g）.Its drug loading co ntent and encapsulation efficiency can reach as high as 14.2% and 47.3%,respectively,using doxorubicin hydrochloride（DOX） as model drug.The DOX-UCNP-Fe3 O4@MSNs-FA system shows excellent sustained drug release and strong pH-dependent performance,in which the drug release would be accelerated at the slightly acidic microenvironment in the tumor;thus,the system can realize the targeted treatment of cancers.The viability of L929 cells demonstrates the good biocompatibility of the composite.Furthermore,DOX-UCNP-Fe3 O4@MSNs-FA exhibits specific cytotoxicity to folate receptor（FR） positive tumor cells,whereas DOX has weak toxicity to FR-negative cells.Therefore,the as-prepared UCNP-Fe3 O4@MSNs-FA can potentially be used as an anti-cancer targeted drug delivery system and enhance the therapeutic efficacy against FR-positive tumor cells.
Xuhua Liang1,2，Jun Fan3，Yanyan Zhao1，Ruyi Jin4
1. College of Biology Pharmacy and Food Engineering,Shangluo University2. Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources3. College of Food Science and Technology,Northwest University4. College of Pharmacy,Shaanxi University of Chinese Medicine
摘 要：Optomagnetic multifunctional composite has attracted much attention in recent years because of its promising application prospect in bioimaging,analysis,detection,disease diagnosis,and targeted drug delivery.To explore a dual-targeted therapy for cancer,a novel class of optomagnetic multifunctional composite（UCNP-Fe3 O4@MSNs-FA） was successfully synthesized by using upconversion nanoparticles（UCNPs） as nucleus,embedding Fe3 O4 nanoparticles into the SiO2 coating layer,and modifying the surface with folic acid（FA） to strengthen its tumor targeting performance.The properties of the composite were extensively studied.The obtained composite possesses excellent upconversion fluorescence,good dispersion,high specific surface area（229.347 m2/g）,and saturation magnetization value（10.9 A m2/g）.Its drug loading co ntent and encapsulation efficiency can reach as high as 14.2% and 47.3%,respectively,using doxorubicin hydrochloride（DOX） as model drug.The DOX-UCNP-Fe3 O4@MSNs-FA system shows excellent sustained drug release and strong pH-dependent performance,in which the drug release would be accelerated at the slightly acidic microenvironment in the tumor;thus,the system can realize the targeted treatment of cancers.The viability of L929 cells demonstrates the good biocompatibility of the composite.Furthermore,DOX-UCNP-Fe3 O4@MSNs-FA exhibits specific cytotoxicity to folate receptor（FR） positive tumor cells,whereas DOX has weak toxicity to FR-negative cells.Therefore,the as-prepared UCNP-Fe3 O4@MSNs-FA can potentially be used as an anti-cancer targeted drug delivery system and enhance the therapeutic efficacy against FR-positive tumor cells.
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