Synergistic effects of Mg-substitution and particle size of chicken eggshells on hydrothermal synthesis of biphasic calcium phosphate nanocrystals
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2020年第1期
论文作者：Wei Cui Qibin Song Huhu Su Zhiqing Yang Rui Yang Na Li Xing Zhang
文章页码：27 - 36
摘 要：Magnesium(Mg2+) ion plays important roles in biomineralization of bone,teeth and calcium carbonate skeletons.Herein,chicken eggshells mainly comprising of Mg-calcite nanocrystals（Mg/（Mg+Ca）2.0 mol.%） were used to fabricate biphasic calcium phosphate（BCP）,a mixture of hydroxyapatite（HA）and p-tricalcium phosphate（p-TCP） nanocrystals,through hydrothermal reactions at 200℃for 24 h.Our results indicated that β-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite,while HA nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal system.Mg substitution in calcite resulted in formation of β-TCP nanocrystals instead of HA crystals through ion-exchange reactions.BCP samples with different compositions（28.6-77.8 wt.% β-TCP） were produced by controlling particle sizes of eggshells for hydrothermal reactions.The larger particles lead to the larger proportion of β-TCP in the BCP composition.Therefore,Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation reactions.Cell culture results showed that the BCP products were non-cytotoxic to MC3 T3-E1 cells,which may be used for bone substitute materials in future.
Wei Cui1,2，Qibin Song3，Huhu Su1,2，Zhiqing Yang1,2，Rui Yang1,2，Na Li1，Xing Zhang1,2
1. Institute of Metal Research, Chinese Academy of Sciences2. School of Materials Science and Engineering, University of Science and Technology of China3. Department of Plastic Surgery, Shengjing Hospital of China Medical University
摘 要：Magnesium(Mg2+) ion plays important roles in biomineralization of bone,teeth and calcium carbonate skeletons.Herein,chicken eggshells mainly comprising of Mg-calcite nanocrystals（Mg/（Mg+Ca）2.0 mol.%） were used to fabricate biphasic calcium phosphate（BCP）,a mixture of hydroxyapatite（HA）and p-tricalcium phosphate（p-TCP） nanocrystals,through hydrothermal reactions at 200℃for 24 h.Our results indicated that β-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite,while HA nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal system.Mg substitution in calcite resulted in formation of β-TCP nanocrystals instead of HA crystals through ion-exchange reactions.BCP samples with different compositions（28.6-77.8 wt.% β-TCP） were produced by controlling particle sizes of eggshells for hydrothermal reactions.The larger particles lead to the larger proportion of β-TCP in the BCP composition.Therefore,Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation reactions.Cell culture results showed that the BCP products were non-cytotoxic to MC3 T3-E1 cells,which may be used for bone substitute materials in future.
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