Interaction between Ternary Rare Earth Complexes of Cinnamic Acid and Phenanthroline with DNA by Spectroscopy
来源期刊：JOURNAL OF RARE EARTHS2005年第2期
论文作者：Zeng Zhengzhi Guo Dongfang Ye Yan
Key words：inorganic chemistry; electrostatic and intercalative mode; EB-DNA quenching fluorescent spectroscopy; absorption spectroscopy; resonance light scattering; rare earth complexes;
Abstract: The interaction of ternary complexes [RE(phen)(cin)3(H2O)](RE= Nd (III),Ce(III),Eu(III))with calf thymus DNA was investigated by electronic absorption spectroscopy, ethidium bromide(EB)-DNA quenching fluorescent spectra and resonance light scattering. All experimental results indicate that the three complexes bind to DNA by the electrostatic mode and the intercalative mode. It is predicted that these complexes show high anticancer activity or other biologic activity.
Zeng Zhengzhi1，Guo Dongfang1，Ye Yan1
(1.College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China)
Abstract:The interaction of ternary complexes [RE(phen)(cin)3(H2O)](RE= Nd (III),Ce(III),Eu(III))with calf thymus DNA was investigated by electronic absorption spectroscopy, ethidium bromide(EB)-DNA quenching fluorescent spectra and resonance light scattering. All experimental results indicate that the three complexes bind to DNA by the electrostatic mode and the intercalative mode. It is predicted that these complexes show high anticancer activity or other biologic activity.
Key words:inorganic chemistry; electrostatic and intercalative mode; EB-DNA quenching fluorescent spectroscopy; absorption spectroscopy; resonance light scattering; rare earth complexes;
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