Fabrication of shish-kebab-structured carbon nanotube/poly（ε-caprolactone） composite nanofibers for potential tissue engineering applications
来源期刊：Rare Metals2019年第1期
论文作者：Tong Wu Xin Chen Jin Sha Yi-Yan Peng Yu-Lu Ma Lin-Sheng Xie Lih-Sheng Turng
文章页码：64 - 72
摘 要：The electrospinning process was applied to fabricate the nanofibers of biodegradable poly（ε-caprolactone）（PCL） in which different contents of multiwalled carbon nanotubes（MWCNTs） were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts（MG-63 cells）. The carbon nanotube（CNT） concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.
Tong Wu1,2,3，Xin Chen1,2,3，Jin Sha1,2，Yi-Yan Peng3，Yu-Lu Ma1,2，Lin-Sheng Xie1,2，Lih-Sheng Turng3
1. Engineering Center of Efficient Green Process Equipment and Energy Conservation, Ministry of Education, East China University of Science and Technology2. School of Mechanical and Power Engineering, East China University of Science and Technology3. Wisconsin Institute for Discovery, University of Wisconsin-Madison
摘 要：The electrospinning process was applied to fabricate the nanofibers of biodegradable poly（ε-caprolactone）（PCL） in which different contents of multiwalled carbon nanotubes（MWCNTs） were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts（MG-63 cells）. The carbon nanotube（CNT） concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.
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