Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys

Shi Jin^1,2，Dan Zhang^1,2，Xiaopeng Lu³，Yang Zhang^1,2，Lili Tan⁴，Ying Liu⁵，Qiang Wang^1,2

1. School and Hospital of Stomatology, China Medical University2. Liaoning Provincial Key Laboratory of Oral Diseases3. Shenyang National Laboratory for Materials Science, Northeastern University4. Institute of Metal Research, Chinese Academy of Sciences5. School of Stomatology, Jiamusi University

摘 要：Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic applications.In this study,the mechanical properties,degradation behaviorand cytocompatibility of MgZn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure Mg.Mechanical tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were excellent.The corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle（α-MEM） medium with 10% fetal bovine serum（FBS） revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time immersion.The metal ion concentrations were consistent with the corrosion rate.Mg-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y alloy.The direct and indirect in vitro tests with MC3 T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and osteogenesis.The results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical,corrosive and biological properties.In summary,these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications.

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