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. Stimulated secretion of fibronectin (FN) influenced the adhesion rates. In addition, AO and MAO modified surfaces promoted cell proliferation through apparent up-regulation of FN and integrin α5... words: titanium; surface modification; Outside-in signaling; fibronectin; integrin 1 Introduction Titanium is an ideal choice for the long-term replacement of hard tissue because of its excellent......
integrin and actin), the proliferation-related gene (c-jun), and the osteoblastic markers genes (type I collagen, osteonectin, alkaline phosphatase, RUNX2 and osteoclain). The results showed that β-TCP......
exhibits a higher cellular uptake via CD44 receptor and integrin receptor mediated endocytosis compared with the GNRs@mSiO2 modified with one receptor or no receptor. In comparison with chemotherapy......
. An adhesion peptide is a short peptide sequence composed of arginyl-glycyl-aspartic acid (RGD), which is a specific ligand of many types of integrin receptors on the cell membrane [21]. Some scholars have... in target cells [33]. RGD is a specific ligand of many integrin receptors on the cell membrane, and it can bind to integrin receptors (α1β1 and αvβ1) along with other integrin receptors on the cell membrane......
are regulated by spacing of integrin ligands [J]. Biophysical Journal, 2007, 92(8): 2964-2974. [16] Webster T J, Ejiofor J U. Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo [J.... The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography [J]. Biomaterials, 2007, 28(10): 1787-1797. [21] CUI Fu-zhai, FENG Qing-ling......
and its alloys via simple chemical surface treatment[J]. Journal of Biomedical Materials Research, 1996, 32(3): 409-417. [14] LIM J Y, TAYBOR A F, LI Z Y, VOGLER E A, DONAHUE H J. Integrin expression......
): 169-194. DOI: 10.1023/A: 1009745219419. [37] PERSSON H, POTRZEBOWSKI W, POTRZEBOWSKA K, SVENSSON L M. Spatial mapping of affinity changes for the integrin LFA-1 during cell migration using clusters......