Polysaccharide-based magnetically responsive polyelectrolyte hydrogels for tissue engineering applications
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2018年第8期
论文作者：Kummara Madhusudana Rao Anuj Kumar Sung Soo Han
文章页码：1371 - 1377
摘 要：Polysaccharide-based bionanocomposite hydrogels with functional nanomaterials were used in biomedical applications.Self-organization of xanthan gum and chitosan in the presence of iron oxide magnetic nanoparticles（Fe3O4MNPs）allowed us to form magnetically responsive polyelectrolyte complex hydrogels（MPECHs）via insitu ionic complexation using D-（+）-glucuronic acid?-lactone as a green acidifying agent.Characterization confirmed the successful formation of（and structural interactions within）the MPECH and good porous structure.The rheological behavior and compressive properties of the PECH and MPECH were measured.The results indicated that the incorporation of Fe3O4MNPs into the PECH greatly improved mechanical properties and storage modulus（G’）.In vitro cell culture of NIH3T3 fibroblasts on MPECHs showed improvements in cell proliferation and adhesion in an external magnetic field relative to the pristine PECH.The results showed that the newly developed MPECH could potentially be used as a magnetically stimulated system in tissue engineering applications.
Kummara Madhusudana Rao1,2，Anuj Kumar1,2，Sung Soo Han1,2
1. School of Chemical Engineering,Yeungnam University2. Department of Nano,Medical and Polymer Materials,Yeungnam University
摘 要：Polysaccharide-based bionanocomposite hydrogels with functional nanomaterials were used in biomedical applications.Self-organization of xanthan gum and chitosan in the presence of iron oxide magnetic nanoparticles（Fe3O4MNPs）allowed us to form magnetically responsive polyelectrolyte complex hydrogels（MPECHs）via insitu ionic complexation using D-（+）-glucuronic acid?-lactone as a green acidifying agent.Characterization confirmed the successful formation of（and structural interactions within）the MPECH and good porous structure.The rheological behavior and compressive properties of the PECH and MPECH were measured.The results indicated that the incorporation of Fe3O4MNPs into the PECH greatly improved mechanical properties and storage modulus（G’）.In vitro cell culture of NIH3T3 fibroblasts on MPECHs showed improvements in cell proliferation and adhesion in an external magnetic field relative to the pristine PECH.The results showed that the newly developed MPECH could potentially be used as a magnetically stimulated system in tissue engineering applications.
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