Preparation and Characterization of AlginateHyaluronic Acid-chitosan based Composite Gel Beads
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2015年第6期
论文作者：胡燕 ZHENG Mengzhu DONG Xiaoying ZHAO Dan 程寒 XIAO Xincai
文章页码：1297 - 1303
摘 要：The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid（HA） and Chitosan（CS） were successfully admixed with Ca2+/alginate（SA） gel system to produce SA/HA/CS gel beads by dual crosslinking: the ionic gelation and the polyelectrolyte complexation. The preparation procedure was that the weight ratio of SA（2%, m/v） to HA（2%, m/v） was kept at 2:1, then the mixture was dripped into the Ca2+ solution for ion-crosslinking, and finally polyelectrolyte crosslinked with 2% low molecular weight CS（LMW-CS） for 1.5 hours. The optimal formulation was achieved by adjusting the concentration and the weight ratio of SA, HA and LMW-CS. Due to the incorporation of HA and LMWCS, the swelling ratio of the beads at pH 7.4 was increased up to 120, and the time for the maximum swelling degree was prolonged to 7.5 h. The swelling behavior was obviously improved compared to the pure SA/Ca2+ system. The preliminary results clearly suggest that the SA/HA/CS gel beads may be a potential candidate for biomedical delivery vehicles.
胡燕1，ZHENG Mengzhu2，DONG Xiaoying1，ZHAO Dan1，程寒1，XIAO Xincai1
1. College of Pharmacy, South-Central University for Nationalities2. School of Pharmacy, Tongji Medical College,Huazhong University of Science and Technology
摘 要：The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid（HA） and Chitosan（CS） were successfully admixed with Ca2+/alginate（SA） gel system to produce SA/HA/CS gel beads by dual crosslinking: the ionic gelation and the polyelectrolyte complexation. The preparation procedure was that the weight ratio of SA（2%, m/v） to HA（2%, m/v） was kept at 2:1, then the mixture was dripped into the Ca2+ solution for ion-crosslinking, and finally polyelectrolyte crosslinked with 2% low molecular weight CS（LMW-CS） for 1.5 hours. The optimal formulation was achieved by adjusting the concentration and the weight ratio of SA, HA and LMW-CS. Due to the incorporation of HA and LMWCS, the swelling ratio of the beads at pH 7.4 was increased up to 120, and the time for the maximum swelling degree was prolonged to 7.5 h. The swelling behavior was obviously improved compared to the pure SA/Ca2+ system. The preliminary results clearly suggest that the SA/HA/CS gel beads may be a potential candidate for biomedical delivery vehicles.
关键词：
