硝苯柳胺的合成

来源期刊：中南大学学报(自然科学版)1999年第5期

论文作者：易健民 施天益 张一甫 成本诚

文章页码：519 - 521

关键词：硝苯柳胺;次氯酸叔丁酯;水杨酸;合成

Key words：niphensamide; t-butyl-hypochlorite; salicylic acid; synthesis

摘    要：以水杨酸、次氯酸叔丁酯和对硝基苯胺 为原料分2步合成了硝苯柳胺．第1步用次氯酸叔丁酯和水杨酸反应合成5-氯水杨酸；第2步用5-氯水杨酸、二氯亚砜和对硝基苯胺反应合成硝苯柳胺．第1步是一种区域专一性反应，杂质极少，从而使第2步反应产物易于提纯．此外，用紫外光谱、红外光谱和核磁共振谱对硝苯柳胺的结构进行了表征．结果表明，产品纯度高达97.9% ，且其收率也可达81%．

Abstract: Niphensamide is synthesized from salicylic acid, t butyl hypochlorite and 4-nitroaniline et al by two steps. In the first step, 5-chloroalicylic acid is synthesized by salicylic acid with t butyl hypochlorite. In the second step, Niphens-amide is synthesized by 5-chlorosalicylic acid, thionyl chloride and 4-nitroaniline. The first step is a regiospecific reac-tion with less impurity, so the product prepared in the second step was purified easily. The results show that the purity of the product is 97.9%, and the yield of the product is 81%. Through the spectrograms of UV, IR, NMR and elementary analysis of the product, the constitutional formula of it is proved to be niphensamide.