Development of a PVA Hydrogel for Bioprosthetic Heart Valve Stent and Other Medical Applications
来源期刊：材料科学与工程学报2000年增刊第2期
论文作者：D.R.Boughner W.K.Wan G.Campbell Z.F.Zhang A.J.Hui
关键词：PVA hydrogel; Bioprosthetic heart valve; stent; design and fabrication; tensile test; fatigue; medical applications;
摘 要：Polyvinyl alcohol (PVA) hydrogel (15%w/w) was processed by freezing and thawing from one through six thermal cycles to obtain wide range of mechanical properties. The materials were tested under uniaxial tension and results show that matching mechanical properties to that of porcine aortic root can be achieved. A fatigue machine for elastomer materials and tissues was built and fatigue test on PVA sample was carried out. The test results show that the PVA has good fatigue property. The stent prototype was designed and successfully made by mold casting method. Some potential medical applications are discussed.
D.R.Boughner1，W.K.Wan4，G.Campbell5，Z.F.Zhang4，A.J.Hui4
(1.Department of Chemical and Medical Biophysics,London,Ontario;
2.Department of Chemical and Cardiology,London,Ontario;
3.University of Western Ontario, The John Robarts Research Institute,London,Ontario;
4.Department of Chemical and Biochemical Engineering,London, Ontario;
5.University of Western Ontario, The John Robarts Research Institute,London, Ontario;
6.The University Campus, London Health Sciences Center, London, Ontario, Canada)
摘要:Polyvinyl alcohol (PVA) hydrogel (15%w/w) was processed by freezing and thawing from one through six thermal cycles to obtain wide range of mechanical properties. The materials were tested under uniaxial tension and results show that matching mechanical properties to that of porcine aortic root can be achieved. A fatigue machine for elastomer materials and tissues was built and fatigue test on PVA sample was carried out. The test results show that the PVA has good fatigue property. The stent prototype was designed and successfully made by mold casting method. Some potential medical applications are discussed.
关键词:PVA hydrogel; Bioprosthetic heart valve; stent; design and fabrication; tensile test; fatigue; medical applications;
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