Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent
来源期刊：JOURNAL OF RARE EARTHS2012年第9期
论文作者：周鑫 杨炼 鄢国平 徐伟 周承凯 张桥 李亮 刘凡 郭俊芳 赵琦
文章页码：884 - 889
摘 要：Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.
周鑫1，杨炼2，鄢国平1，徐伟1，周承凯2，张桥1，李亮1，刘凡1，郭俊芳1，赵琦1
1. School of Materials Science and Engineering, Wuhan Institute of Technology2. Center for Magnetic Resonance Imaging of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
摘 要：Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.
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