In vivo optical bioimaging by using Nd-doped LaF3 luminescent nanorods in the second near-infrared window
来源期刊：Journal of Rare Earths2019年第9期
论文作者：Shouyan Cheng Liu Liu Qiuhua Yang Youbin Li Songjun Zeng
文章页码：931 - 936
摘 要：Fluorescent imaging in the second near-infrared（NIR-Ⅱ, 1000-1700 nm） region has attracted enormous research interest due to its advantages of unprecedentedly improved imaging sensitivity and spatial resolution. Herein, high quality NIR-Ⅱ emissive LaF3:Nd3+ nanorods（NRs） with hexagonal phase structure and controlled size were synthesized by a hydrothermal method. And the Nd3+ doping induced NIRⅡ luminescent intensity evolution was studied, In vivo NIR-Ⅱ bioimaging and real-time tracking reveal that these LaF3:Nd3+ NRs are mainly accumulated in liver and spleen. Moreover, in vivo toxicity assessment demonstrates that LaF3:Nd3+ NRs feature low biotoxicity and good biocompatibility in living animals. Therefore, the NIR-Ⅱ emitting hexagonal phase LaF3 NRs with controlled size are promising probes for optical bioimaging.
Shouyan Cheng，Liu Liu，Qiuhua Yang，Youbin Li，Songjun Zeng
Synergetic Innovation Center for Quantum Effects and Application,Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education,School of Physics and Electronics,Hunan Normal University
摘 要：Fluorescent imaging in the second near-infrared（NIR-Ⅱ, 1000-1700 nm） region has attracted enormous research interest due to its advantages of unprecedentedly improved imaging sensitivity and spatial resolution. Herein, high quality NIR-Ⅱ emissive LaF3:Nd3+ nanorods（NRs） with hexagonal phase structure and controlled size were synthesized by a hydrothermal method. And the Nd3+ doping induced NIRⅡ luminescent intensity evolution was studied, In vivo NIR-Ⅱ bioimaging and real-time tracking reveal that these LaF3:Nd3+ NRs are mainly accumulated in liver and spleen. Moreover, in vivo toxicity assessment demonstrates that LaF3:Nd3+ NRs feature low biotoxicity and good biocompatibility in living animals. Therefore, the NIR-Ⅱ emitting hexagonal phase LaF3 NRs with controlled size are promising probes for optical bioimaging.
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