Plasma spray of biofunctional（Mg, Sr）-substituted hydroxyapatite coatings for titanium alloy implants
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2019年第5期
论文作者：Lei Cao Ihsan Ullah Na Li Shiyu Niu Rujie Sun DANDan Xia Rui Yang Xing Zhang
文章页码：719 - 726
摘 要：Plasma-sprayed hydroxyapatite（HA） coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA（（Mg, Sr）-HA） nano-scale powders have been synthesized, which are further used to prepare（Mg, Sr）-HA coatings on Ti-6 Al-4 V alloys in order to improve the biological functions. The average size of（Mg, Sr）-HA nano particles is ～75 nm. The average bonding strength for（Mg, Sr）-HA coating and samples after heat treatment at 500°C or 600°C for 3 h are26.17 ± 2.11 MPa, 36.07 ± 4.48 MPa and 37.07 ± 2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment. MC3 T3-E1 cells show a high proliferation rate when cultured with（Mg, Sr）-HA coating extract compared to the normal culture medium, which also exhibit large extension and deposition of extracellular matrices when adhered on the coating surfaces. Thus, these（Mg, Sr）-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry.
Lei Cao1,2，Ihsan Ullah1,3，Na Li1，Shiyu Niu4，Rujie Sun5，DANDan Xia4，Rui Yang1,3，Xing Zhang1,3
1. Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences2. University of the Chinese Academy of Sciences3. School of Materials Science and Engineering, University of Science and Technology of China4. Shenyang Pharmaceutical University5. University of Utah
摘 要：Plasma-sprayed hydroxyapatite（HA） coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA（（Mg, Sr）-HA） nano-scale powders have been synthesized, which are further used to prepare（Mg, Sr）-HA coatings on Ti-6 Al-4 V alloys in order to improve the biological functions. The average size of（Mg, Sr）-HA nano particles is ～75 nm. The average bonding strength for（Mg, Sr）-HA coating and samples after heat treatment at 500°C or 600°C for 3 h are26.17 ± 2.11 MPa, 36.07 ± 4.48 MPa and 37.07 ± 2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment. MC3 T3-E1 cells show a high proliferation rate when cultured with（Mg, Sr）-HA coating extract compared to the normal culture medium, which also exhibit large extension and deposition of extracellular matrices when adhered on the coating surfaces. Thus, these（Mg, Sr）-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry.
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