Inherently radiopaque polyurethane beads as potential multifunctional embolic agent in hepatocellular carcinoma therapy
来源期刊:JOURNAL OF MATERIALS SCIENCE TECHNOLOG2021年第4期
论文作者:Wenhuan Wang Lin Sang Yiping Zhao Zhiyong Wei Min Qi Yang Li
摘 要:The aim of the current study is to report an inherently radiopaque drug-eluted beads(DEBs) as promising embolic materials for TACE techniques. Firstly, the synthesized radiopaque iodinated polycaprolactonepolyurethanes(I-PCLUs) are synthesized by chain-extending method by using 4, 4-′isopropylidinedi-(2,6-diiodophenol)(IBPA) as the radiopacifying agent. Then, doxorubicin(Dox) is introduced as a chemotherapeutic agent into I-PCLU beads via a double emulsification(W/O/W) method. The drug loading and controlled release behavior of two ratios of I-PCLU/Dox are found to be dependent upon the internal porous microstructure, and the radiopacity is well-retained after four weeks drug release. Besides,the I-PCLU/Dox beads exhibit positive in vitro anti-tumor effect. The in vivo intramuscular implantation and liver embolization results demonstrate that I-PCLU beads have good histocompatibility, occlusion effect and X-ray traceability. Furthermore, the drug-loaded I-PCLU beads are performed into a VX2 rabbit hepatocellular carcinoma(HCC) model using a micro-catheter, form embolization of hepatic arteries and inhibit the tumor growth after one week post-injection. Hence, this polymeric system provides a potential radiopaque chemoembolization candidate for HCC and other cancer therapies, which could bring opportunities to the next generation of multifunctional embolic agents.
Wenhuan Wang1,Lin Sang2,Yiping Zhao3,Zhiyong Wei1,Min Qi4,Yang Li1
1. State Key Laboratory of Fine Chemicals, Liaoning Key Laboratory of Polymer Science and Engineering, Department of Polymer Science and Engineering,School of Chemical Engineering, Dalian University of Technology2. School of Automotive Engineering, Dalian University of Technology3. Department of Radiology, Second Affiliated Hospital of Dalian Medical University4. School of Material Science and Engineering, Dalian University of Technology
摘 要:The aim of the current study is to report an inherently radiopaque drug-eluted beads(DEBs) as promising embolic materials for TACE techniques. Firstly, the synthesized radiopaque iodinated polycaprolactonepolyurethanes(I-PCLUs) are synthesized by chain-extending method by using 4, 4-′isopropylidinedi-(2,6-diiodophenol)(IBPA) as the radiopacifying agent. Then, doxorubicin(Dox) is introduced as a chemotherapeutic agent into I-PCLU beads via a double emulsification(W/O/W) method. The drug loading and controlled release behavior of two ratios of I-PCLU/Dox are found to be dependent upon the internal porous microstructure, and the radiopacity is well-retained after four weeks drug release. Besides,the I-PCLU/Dox beads exhibit positive in vitro anti-tumor effect. The in vivo intramuscular implantation and liver embolization results demonstrate that I-PCLU beads have good histocompatibility, occlusion effect and X-ray traceability. Furthermore, the drug-loaded I-PCLU beads are performed into a VX2 rabbit hepatocellular carcinoma(HCC) model using a micro-catheter, form embolization of hepatic arteries and inhibit the tumor growth after one week post-injection. Hence, this polymeric system provides a potential radiopaque chemoembolization candidate for HCC and other cancer therapies, which could bring opportunities to the next generation of multifunctional embolic agents.
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