Abstract: α-tricalcium phosphate(α-TCP)/tetracalcium phosphate(TTCP) composite bone cement (CPC) has good hydration characteristic. CPC powder mixture is mixed with water at a powder/liquid (P/L) ratio of 1.50g/mL. The setting time can be adjusted, the maximal compressive strength is 45.36MPa, and the hydration product is hydroxyapatite (HAP). In vitro biological simulated experiments indicate that α-TCP/TTCP bone cement has certain dissolubility. The hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 weeks. The results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response, no muscle stimulation, no haemolysis, no cruor and no inflammatory reaction, no exclusion response are caused by α-TCP/TTCP cement, which contributes to bone tissue spreading and impinging. α-TCP/TTCP cement hydrates and hardens continually in vivo. The materials fuse with host bone together with implanting time prolonging. α-TCP/TTCP composite bone cement has good biocompatibility and bioactivity, certain biodegradation and good osteogenesis as well. It is qualified as an artificial bone material.
tricalcium phosphate (α-TCP) /tetracalcium phosphate (TTCP) composite bone cement (CPC) has good hydration characteristic. CPC powder mixture is mixed with water at a powder/liquid (P/L) ratio of 1.50 g/mL. The setting time can be adjusted, the maximal compressive strength is 45.36 MPa, and the hydration product is hydroxyapatite (HAP) . In vitro biological simulated experiments indicate that α-TCP/TTCP bone cement has certain dissolubility. The hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 weeks. The results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response, no muscle stimulation, no haemolysis, no cruor and no inflammatory reaction, no exclusion response are caused by α-TCP/TTCP cement, which contributes to bone tissue spreading and impinging. α-TCP/TTCP cement hydrates and hardens continually in vivo. The materials fuse with host bone together with implanting time prolonging. α-TCP/TTCP composite bone cement has good biocompatibility and bioactivity, certain biodegradation and good osteogenesis as well. It is qualified as an artificial bone material.