Synthesis of mesoporous core-shell structured GdPO4:Eu@SiO2@mSiO2 nanorods for drug delivery and cell imaging applications
来源期刊:Journal of Rare Earths2020年第10期
论文作者:Yanli Wu Xianzhu Xu Xiuli You Qiang Xiao
文章页码:1086 - 1092
摘 要:Mesoporous GdPO4:Eu@SiO2@mSiO2 core-shell nanorods(NRs) were prepared by a facile two-step method.First,the monodispersed GdPO4:Eu NRs were obtained on a large scale via a facile precipitation method,then mesoporous silica was wrapped onto their surface through hydrolysis of tetraethylorthosilicate(TEOS).The XRD result indicates that the as-prepared GdPO4:Eu NRs core has hexagonal phase.The FTIR and the N2 adsorption/desorption isotherm analysis confirm the successful coating of mesoporous silica.The TEM images show that the obtained GdPO4:Eu@SiO2@mSiO2 NRs exhibit uniform monodisperse core-shell structure with a nanorod core(length of 200 nm;width of 20 nm),and mesoporous silica shell of 15 nm.Under excitation of 274 nm,GdPO4:Eu@SiO2@mSiO2 NRs show strong red luminescence from 5 D0→7 FJ(J=1,2,3 and 4) transitions of Eu3+.Furthermore,the GdPO4:Eu@-SiO2@mSiO2 NRs exhibit obvious T1 enhancement effect due to paramagnetism of Gd3+.The drug loading capacity and pH-sensitive releasing behavior of the as-prepared GdPO4:Eu@SiO2@mSiO2 NRs were studied by using doxorubicin(DOX) as model drug.The excellent biocompatibility of GdPO4:Eu@-SiO2@mSiO2 NRs was demonstrated by MTT assay.Taken together,the mesoporous GdPO4:Eu@-SiO2@mSiO2 NRs may be potentially applied in fields of drug delivery and dual-modal imaging.
Yanli Wu1,Xianzhu Xu2,Xiuli You1,Qiang Xiao1
1. Jiangxi Key Laboratory of Organic Chemistry,Jiangxi Science and Technology Normal University2. College of Life Science,Jiangxi Normal University
摘 要:Mesoporous GdPO4:Eu@SiO2@mSiO2 core-shell nanorods(NRs) were prepared by a facile two-step method.First,the monodispersed GdPO4:Eu NRs were obtained on a large scale via a facile precipitation method,then mesoporous silica was wrapped onto their surface through hydrolysis of tetraethylorthosilicate(TEOS).The XRD result indicates that the as-prepared GdPO4:Eu NRs core has hexagonal phase.The FTIR and the N2 adsorption/desorption isotherm analysis confirm the successful coating of mesoporous silica.The TEM images show that the obtained GdPO4:Eu@SiO2@mSiO2 NRs exhibit uniform monodisperse core-shell structure with a nanorod core(length of 200 nm;width of 20 nm),and mesoporous silica shell of 15 nm.Under excitation of 274 nm,GdPO4:Eu@SiO2@mSiO2 NRs show strong red luminescence from 5 D0→7 FJ(J=1,2,3 and 4) transitions of Eu3+.Furthermore,the GdPO4:Eu@-SiO2@mSiO2 NRs exhibit obvious T1 enhancement effect due to paramagnetism of Gd3+.The drug loading capacity and pH-sensitive releasing behavior of the as-prepared GdPO4:Eu@SiO2@mSiO2 NRs were studied by using doxorubicin(DOX) as model drug.The excellent biocompatibility of GdPO4:Eu@-SiO2@mSiO2 NRs was demonstrated by MTT assay.Taken together,the mesoporous GdPO4:Eu@-SiO2@mSiO2 NRs may be potentially applied in fields of drug delivery and dual-modal imaging.
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