季铵盐A-1催化合成邻硝基苯甲酸
来源期刊：中南大学学报(自然科学版)2001年第4期
论文作者：李树华 李晓如 陈帅华
文章页码：379 - 381
关键词：季铵盐A-1;相转移催化;邻硝基甲苯;邻硝基苯甲酸;高锰酸钾;合成
Key words：quaternary ammonium salt A-1; phase transfer catalysis; O-nitrotoluene; O-nitrobenzoic acid; potassium permanganate; synthesis
摘 要：研究了季铵盐A-1催化高锰酸钾氧化邻硝基甲苯,合成邻硝基苯甲酸的反应,考察了不同相转移催化剂的催化活性、催化剂用量、反应温度、反应时间、KMnO4用量和反应体系酸碱性对反应的影响.在优化反应条件下,即以季铵盐A-1为相转移催化剂,高锰酸钾与邻硝基甲苯的量比为2.5∶1,反应温度为95℃,反应时间为3 h,在中性条件下进行反应,产物收率可达95%.实验结果表明,季铵盐A-1对于高锰酸钾氧化邻硝基甲苯合成邻硝基苯甲酸,是1种优良的相转移催化剂.
Abstract: The catalytic synthesis of O-nitrobenzoic acid (ONBA) with phase transfer catalyst (PTC), quaternary ammonium salt A-1, is reported. The effects of different factors, such as PTC amount, PTC activity, reaction temperature and time, potassium permanganate amount and basicity and acidity of reaction system, on the yield of ONBA were investigated. Under the optimal reaction conditions the reaction underwent for 3 h at 95℃with A-1 as PTC in neutral reaction system, the mole ratio of potassium permanganate to O-nitrotoluene was 2.5∶1, and the yield of ONBA was 95.0%. The experiment results showthatA-1 is a good PTC for synthesis of ONBA with O-nitrotoluene by oxidation of potassium permanganate.
